After surgery and 30 treatments of radiation with mild doses (140/MG per night) doses of temodar during that time. Me oncologist is recommending a year of a cyclical series of 5 days per month of larger does of Temodar for a full year. He says there will be no nausea with this drug. I didn't experience it the last time except at the end when finishing the radiation/temodar series. The Compazine was basically useless for me. The nurse for my neurologist is recommending I ask for Zofran.

-You might also ask about Kytril. Both drugs are potent HT3 receptor blockers. They block the receptors that cause most chemotherapy nasuea. Both are also very expensive in the USA, however the clinical data show they are vastly superior to other anti-nausea agents.

While not wishing to stir the pot, many insurance companies don't like paying for these drugs, however they are available from pharacies outside the USA at a fraction of the USA price. Something you might wish to consider if your insurance declines to pay for these drugs or seriously limits them.

-My fiancee has had 4 cycles of Temodar. The biggest recommendation that I can give is that you REALLY need to take the anti-nausea meds w/ it. with it - especially Zofran. We didn't know how important it was the first time he took it and he was violently sick.

Honestly, my fiancee has had kind of a rough time w/ Temodar in terms of nausea - he has yet to make it through a cycle without vomiting, but everything that I'm seeing indicates that his experience is really unusual and it's well tolerated for most people.

I'd also recommend the Temodar website (I think I joined that through e-groups.com)- lot of information and the people there are really helpful.