 | Carboplatin+Paclitaxel+surgery clin. trial experience |
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I'm posting for a friend who was recently diagnosed w/ stage II
adenocarinoma of the lung. Her physicians have recommended
that she enter a trial - SWOG-S9900 - which will evaluate chemo
administered pre-surgery vs. chemo administered post-surgery.
We would be interested in hearing from anyone who has
participated in this trial, or has anything else to say about this
drug regimen or this disease, any good links to check out,
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Carboplatin has been the mainstay of lung cancer chemotherapy and paxlitaxel
has been showing some good results. An oncologist friend indicated that
carboplatin and paclitaxel are the favored combination though the literature
and the nci website shows a variety of others. We can say with relative
certainty that mult-modal chemotherapy, use of various drugs, achieves better
results than a particular drug. Which combination achieves the best results
remains to be seen. I cannot give you advice but I would have mixed feelings about a clinical trial
for a stage 2 patient. At stage 4 (advanced metastatic cancer) the argument
for participation is clearer, we do not know what works so some experimentation
could be helpful. Stage 2 does have a particular program. That said, it is not
clear whether pre-surgery chemo is better.
I would ask your doctor, rather than participating in this trial, shouldn't I
simply get the treatment that you think is best. His answer may be that he
believes pre-surgery chemotherapy could be helpful, but he cannot provide it
outside a clinical setting, since it remains experimental. Hope this helps. (I am not a doctor, but I am completing a book on lung cancer.)
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