i did 7 months (complications) of CMF, and aside from the nausea, you can expect taste bud problems (metalic taste to food), mild to extreme hair loss (i kept most of mine, except on top...) fatigue, and either total menopause or menopausal sypmptoms. i had no changes in my menstrual cycle until almost 1 year after beginning chemo, but then went into "ovarian failure" but contrary to what the doc's said, i am still ovulating and capable of bearing children. my hair grew back, tho thinner than it was... i used to have a mix of blond, brown and red hair. now i have dark brown with grey. if your wife's a red head, look out. for some reason, red heads seem to have diverse and complicated reactions to chemo - none of them good. fyi, there is a great breast cancer support list available from the L-Soft list server at Memorial University of Newfoundland. it's the "Breast-Cancer List" and i'm not sure how i found it, but if you do a search on breast cancer, you'll find the "list server" listing, and be able to follow directions on getting on board. these folks (on the bc-list) are a wealth of info and support, and i highly suggest that you sign on.