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Does anyone have any information on or experience with the side effects, both long and short term, of cisplatinum.Chemotherapy Source Book?


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-Here is some info from the Testicular Cancer Physician Info page:

Since the majority of testis cancer patients who receive chemotherapy are curable, it is important to be aware of possible long-term effects of platinum-based treatment:

1. Fertility: Many patients have oligospermia or sperm abnormalities prior to therapy. Virtually all become oligospermic during chemotherapy. However, many recover sperm production and can father children. The children do not appear to have an increased risk of congenital malformations.[11-13]

2. Secondary leukemias: Scattered reports of secondary acute leukemia, primarily non-lymphocytic, have appeared. In some cases, they were associated with the prolonged use of alkylating agents or with the use of radiation.[14] One group, however, has reported secondary non-lymphocytic leukemia associated with treatment with bleomycin, etoposide, and platinum
(BEP).[15] The leukemia appeared to be related to the cumulative dose of etoposide, since five cases occurred among 82 patients receiving more than 2000 mg/m2 and none occurred in 130 patients who received less than 2000 mg/m2.

3. Renal function: minor decreases in creatinine clearance occur (about a 15% decrease, on average) during platinum-based therapy, but these appear to remain stable in the long term, without significant deterioration.[16]

4. Hearing: Bilateral hearing deficits occur with cisplatin-based chemotherapy, but they generally occur at sound frequencies of 4 to 8 kHz, outside the range of conversational tones.[16] Therefore, hearing aids are rarely required at standard doses of cisplatin.

-I think the best place to start would be a general oncology text, such as Principles and Practice of Cancer, or a text on chemotherapy in general such as The Chemotherapy Source Book. While these are medical texts, they'll have enough pertinent information for you.

 


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