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oral chemotherapy for colon cancer

My dad was diagnosed with colon cancer, which had metastisized to his liver, two years ago this month. He had all of the cancer removed from his colon and has tried several things for the tumors in his liver, including therasphere. He's managed to decrease the size of them a little, by taking Xeloda, immune system supplements, and going on a strict no-sugar, no-animal fat diet. His CEA dropped way down to 4 at its lowest, but in the last month, it has gone up from around 8 to 18. He's going in to try ablation in the next couple of weeks. All in all we're amazed at how well he's done, as the prognosis wasn't very good at the start. Now we're thinking he needs to find a new kind of chemotherapy to try, since the Xeloda may eventually stop working. We're looking for a low dose oral chemotherapy that's not Xeloda. Is anyone aware of such a drug that is available outside clinical trials?


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-I don't know of any oral drug outside of Xeloda that's available for colon cancer, though Lowkey is probably better informed.

Probably the best person to ask is your dad's oncologist. He/she would be the best informed on the topic.

I don't know of ANY oral form of chemo outside of xeloda - at least not for colon cancer. Michele and I have 'done' just about everything for colon/rectal cancer and the current protocols seem to be

-I've spoke to him via email and he says it will be a long time before his work bears fruits if it ever does. He was even kind enough to supply me with information on where these chemicals exist in plants naturally and some research paper links. He also said if he sees any trials on these chemicals he would get in touch - maybe someone in here knows about any?
(The chemicals are called annonaceous acetogenins, highly toxic to cancer cells leaving normal cells intact and are being targeted at MDR strains of cancer (multi drug resistant)) I was reading that one of these chemicals was particularly effective against colon cancer and almost 10,000x more toxic to cancer cells than a current chemodrug. I asked one of the doctors treating my mother what he thought - he said the evidence was there, just it hasn't gone through trials yet.

 


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