-'Kill from replicating'? If you mean is it trying to provide a nucleotide analogy that when made available allows the replicating virus to waste its time making inactive copies of itself, well yes.

All 'anti-biotics' are to some degree a 'chemotherapy' and potentially harmful to the patient too - the goal is to find one that is many times more harmful to the target than it is the host. Fortunately with bacteria, we have ways we can attack their cell wall synthesis and the like that have virtually no side effects on the mammalian hosts.

HIV is a retrovirus and as you should know, RNA uses some different nucleotides in its replication than DNA. Since there isn't lots of RNA replication going on in the human body (most RNA activity is DNA->RNA->protein systhesis) it was hoped that by introducing a bogus RNA nucleotide look alike (analog) that the replicating HIV virus would grab this molecule and use it when it replicated, resulting in a biologically inactive copy.

The problem with high dose AZT alone is that it also interfered with some host functions. Hence some of the side effects. The HAART cocktails mix lower doses of analogs and other newer drugs, trying to hit the virus at many points, while keeping the interference with necessary host systems at a minimum. The ideal of course would be to find agents that affected HIV alone, and the search continues.

As a previous poster in this thread pointed out if there were such a agent known they'd be using it to create 'AIDS' laboratory animals for testing purposes. As far as I know there is no known substance or combination of substances that will cause an isolated CD4 T cell depletion. In light of the reasonable assumption that researchers would be highly motivated to do so, its unlikely that any such agent exists. Obviously something might be found inthe future, but its sure ain't 'poppers', 'bactrim', low-fat milk, or any other easily tested item.