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I am seeking to license an antimicrobial agent for use in beverages.
The agent must be dilute and suitable for human ingestion and chemotherapy,
as well as able to function in an acidic environment rich in calcium. In
addition, it would be advantageous for the agent to be able to function in
the presence of hard water ions as well for cleaning hard surfaces. Both
"off-the-shelf" solutions to this problem and R&D concepts with proof of
feasibility are of interest.
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-Olive leaves have an antimicrobial agent called oleuropein that is
so antimicrobial that it actually kills the yeast used to ferment
olive oil. Consequently, the olive leaves were always a source of
irritation to the olive oil manufacturers and so they burned them.
Now they find that this antimicrobial factor that was ruining their
olive oil is very valuable, bringing them substantial income. Olive leaves kill fungi, bacteria, viruses, protozoa, worm parasites.
The olive leaf extract is actually an extract of oleuropein, which
has 23 ingredients, two of which are vital. One of those is elenic
acid, which combined with a calcium salt of elenic acid called calcium
elanate is the chief ingredient in eliminating pathogenic microbes. In an Upjohn study in 1969 in the Journal Antimicrobial Agents and
Chemotherapy, the lead researcher, Harold E. Renis, reported that
calcium elenolate inhibited a number of viruses, including
parainfluenza, herpes, pseudorabies, vesicular stomatitis,
encephalomyocarditis, Newcastle disease, some forms of polio, and
Sindbis. Every virus exposed to calcium elenolate, except for reovirus
and poliovirus, were inactivated. (Renis HE. In Vitro Antiviral
Activity of Calcium Elenolate. Antimicrobial Agents and Chemotherapy.
1969, pps. 167-72.)
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