Stage IIA Sentinel Lymph node: Not involved Size: 2.8 cm Histopathlogic Grade III Estrogen Receptors : Negative (no estrogen therapy) Her 2 : Results not available yet Margins: Clear Metastasis: No evidence of any metastasis (CT scan/MRI/ultrasound)

She recently had a modified masectomy.

She is a 65 year old, otherwise, healthy woman. We are debating whether adjuvant chemotherapy would do her more harm than good. Given than she is 65, we are concerned that chemotherapy would irreversibly harm her health.

Can someone point me to any good research sources/papers on this subect.

-Adjuvant combination chemotherapy with cyclophosphamide, methotrexate, and fluorouracil was administered after radical mastectomy for primary breast cancer with histologically positive axillary lymph nodes to assess whether it would improve treatment outcome as compared with surgery alone. Here we report a 20-year follow-up of this investigation.

-There's another one there that says "new management" but there's nothing on the page http://www.bccancer.bc.ca/HPI/CancerManagementGuidelines/ If I click on the word Breast, it seems to take me back to the first one, I'm posting. I think they were just working on the site. http://www.bccancer.bc.ca/NR/exeres/