I know about the big side effect can be liver toxicity, and I will have to have liver function tests once a month to keep track. I would like to know if anyone else has ever taken this medication, and if they had any other side effects. Any advice?

-I have discussed this drug with my doctor. He is of the opinion that Methotrexate is not very effective at treating asthma. We tried Cyclosporine and it works great. I am on a much lower dose than what is recommended for transplant patients. I am happy with the results and am starting to wean off of it.

I am also trying gammaglobulin replacement therapy. This with the Cyclosporine has changed my life dramatically.

For side effects of the Methotrexate go to http://www.rxlist.com/cgi/generic/mtx_ad.htm#DI. This is the adverse reaction section for Methotrexate.

-I took MTX for 1 year back in 94-95 and it successfully got me off long term use of predisone. I too asked on this list for feedback from others taking MTX when I started it. I'll include the two response I got back then below. The only side effect I had was a very very slight nausea most of the time.

I know of others that have had bad experiences with MTX. Some have had bad reactions to it so be sure to monitor yourself for any signs of respitory problem the first day you take it and get to the ER if you do.

From the other posts it looks like there is much more info today than there was 5 years ago when treating asthma with MTX was just making its way out of research to the public.